Geographical variation of the furanocoumarin composition of the fruits of Icelandic Angelica archangelica.

Inhibition of acetylcholinesterase by extracts and constituents from Angelica archangelica and Geranium sylvaticum.

The aim of this study was to explore the acetylcholinesterase (AChE) inhibition of several Icelandic medicinal herbs. Ethanolic extracts of Angelica archangelica seeds and the aerial parts of Geranium sylvaticum proved effective, with IC50 values of 2.20 mg/ml and 3.56 mg/ml, respectively. The activity of imperatorin and xanthotoxin from A. archangelica was measured. Xanthotoxin proved much mor...

Antiproliferative effect of Angelica archangelica fruits.

The aim of this work was to study the antiproliferative effect of a tincture from fruits of Angelica archangelica and the active components using the human pancreas cancer cell line PANC-1 as a model. Significant dose-dependent antiproliferative activity was observed in the tincture with an EC50 value of 28.6 microg/ml. Strong antiproliferative activity resulted from the two most abundant furan...

Division of Pharmaceutical Biology Faculty of Pharmacy University of Helsinki Plant secondary metabolites in Peucedanum palustre and Angelica archangelica and their plant cell cultures

Accumulation of essential oils in relation to root differentiation in Angelica archangelica L.

The accumulation of essential oils in Angelica archangelica subsp. archangelica roots at different developmental stages was investigated through histochemical and chemical analyses. Roots less than 1 mm in diameter showed a primary diarch structure and two primary secretory ducts in the pericycle. These ducts were ephemeral and probably became dysfunctional early on. Oil accumulation was observ...

Evaluation of Antiseizure Activity of Essential Oil from Roots of Angelica archangelica Linn. in Mice

In the present study, the effect of essential oil of the root of Angelica archangelica Linn. was evaluated against electrically and chemically induced seizures. The seizures were induced in mice by maximal electroshock and pentylenetetrazol. The effect of essential oil of the root of Angelica archangelica on seizures was compared with standard anticonvulsant agents, phenytoin and diazepam. The ...